VP24 Is a Molecular Determinant of Ebola Virus Virulence in Guinea Pigs
نویسندگان
چکیده
منابع مشابه
VP24 is a molecular determinant of Ebola virus virulence in guinea pigs.
In sharp contrast to human and nonhuman primates, guinea pigs and some other mammals resist Ebola virus (EBOV) replication and do not develop illness upon virus inoculation. However, serial passaging of EBOV in guinea pigs results in a selection of variants with high pathogenicity. In this report, using a reverse genetics approach, we demonstrate that this dramatic increase in EBOV pathogenicit...
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UNLABELLED Ebola virus (EBOV) transmission is currently poorly characterized and is thought to occur primarily by direct contact with infectious material; however transmission from swine to nonhuman primates via the respiratory tract has been documented. To establish an EBOV transmission model for performing studies with statistical significance, groups of six guinea pigs (gps) were challenged ...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2011
ISSN: 0022-1899,1537-6613
DOI: 10.1093/infdis/jir338